Custom Media and Liquid Manufacturing

LSG can manufacture a broad variety of liquids, including cell culture media, buffers, serum and process liquids. We operate several production spaces, enabling us to manufacture both sterile and non-sterile products packed into tubes, bottles or bags. We can accommodate highly specific requirements and strict QC release criteria, and can provide kitting services to pack your products into end-user-ready formats.

Yes. LSG can support the technical considerations required to move a formulation towards manufacture, including raw material and excipient selection, manufacturing requirements and specification development. Where appropriate, we can also suggest alternative raw materials from trusted suppliers that may provide technical, supply-chain or cost advantages.

Customer-developed formulations can be transferred into the LSG manufacturing environment. The formulation, manufacturing process, raw materials, quality requirements and finished-product specification are reviewed and agreed jointly with you before manufacture begins. A pilot batch is often required before progressing to full-scale manufacture.

Transferring a formulation from the lab to full-scale manufacture introduces many variables. Where appropriate, we suggest a pilot or trial batch before routine production. This demonstrates that the formulation transfers successfully into the proposed process and lets us assess mixing, raw materials, filtration, filling, packaging and quality requirements before scaling up.

No. We pride ourselves on agile, responsive support for early-stage companies. Smaller-scale manufacturing can be used for evaluation, trials or validation before larger-scale production. This is particularly useful for new formulations, new packaging formats or where further market validation is needed before full commercial scale.

Manufacturing is available from small trial or validation batches through to production volumes of up to 2,000 litres. The right batch size depends on the product, manufacturing process, development stage and packaging requirements.

LSG operates an ISO 13485 and ISO 9001 registered quality system, and production processes are GMP-aligned. Manufacture can follow LSG Standard Operating Procedures or customer-defined procedures, depending on the project. Lower-specification manufacturing is available where the end application does not require such stringent production controls.

Specification and documentation requirements are discussed at the start of the project. Specifications are developed jointly with you and agreed before manufacture progresses, so the manufacturing process, quality requirements and release criteria are defined at the point of quotation.

QC release requirements are agreed as part of the project specification. Testing is performed in our own laboratory and through external testing laboratories where required, and the quality documentation can be structured to meet your requirements. We can also offer bespoke protocol development and specialist testing.

Yes. LSG maintains traceability of raw materials and consumables throughout manufacture. We are International Serum Industry Association (ISIA) Traceability Certified for the handling of animal-derived materials, and apply the same traceability principles across all manufacturing activities.

Yes. LSG provides cleanroom production, sterile filtration and aseptic filling. Independent sterility testing can be incorporated, and additional sterilisation options including gamma irradiation and autoclaving are available depending on the product and packaging format.

LSG operates ISO Class 5 and Class 7 cleanrooms, including a Grade C/Grade D cleanroom suite designed for GMP-aligned manufacture of products that do not contain animal-derived materials. Products can be supplied for Research Use Only or for onward manufacture.

We support a wide range of packaging and filling formats, including PET and PETG bottles, sterile single-use bags, IBCs, vials, tubes and other small-volume containers. Customer-supplied or customer-specified closures can be accommodated where appropriate. Container and closure types may need to be validated before full manufacture.

Yes. Products can be supplied with LSG labelling or customer-designed labels carrying the required product information and branding. Labelling requirements are built into the agreed project specification.

LSG can assist with shelf-life determination, including accelerated shelf-life studies across a range of temperatures. A full list of LSG Lab Services is available on request.

Storage is available at ambient temperature, +4°C and -20°C, with -80°C and liquid nitrogen storage for particularly temperature-sensitive products. Off-site storage and drop shipment services are also available.

Existing IP remains the property of the customer. Projects can be protected by non-disclosure agreements, with formulation information controlled through restricted access and electronic document-control systems.

Our Quality and Regulatory team can support quality testing and the preparation of technical files and other supporting documentation. Depending on your requirements, this support may be chargeable. All GMP-aligned manufacture has a full document suite, available on request.

Every project is different, but a typical programme runs from an initial technical discussion, through formulation and specification review, process transfer or development, a pilot or validation batch, and review and optimisation, to routine manufacture with quality release and supply. The work needed at each stage depends on how developed the product and process are when the project begins.